Characterization of a protein corona formation
on single EVs using super-resolution imaging

Super-resolution microscopy helps better characterize small structures under 200 nm in size, such as Extracellular Vesicles and their associated proteins. A recent study by Martin Wolf and colleagues from the laboratory of Prof. Dirk Strunk at the Paracelsus Medical University used the Nanoimager to study the functionality of allogeneic placental-expanded stromal cell EVs with or without a protein corona.

Check the application note below to learn how Wolf et al used two-color dSTORM imaging to directly visualize and characterize the protein corona associated with individual EVs. Importantly, EVs depleted of this corona were no longer functional in proangiogenesis and immunomodulation.

App Note image - Characterization of a protein corona formation on single EVs using super-resolution imaging

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