In this app note, we discuss how super-resolution microscopy can be used to detect and quantify EV cargo
The Nanoimager enables visualization and detection of proteins and genetic material simultaneously within the lumen and on the surface of individual EVs with single-molecule sensitivity.
In this application note we discuss how characterization of sub-populations of EVs possessing one or more biomarkers enables:
• Distinction of molecules within the lumen or on the surface of EVs
• Association of unique molecular signatures to EVs of a specific size
• Investigation of the function of DNA on the EV surface
• Understanding the unique role of EV subtypes in cancer and other diseases