EV cargo: visualizing and quantifying molecular DNA in single-EVs

The Nanoimager enables visualization and detection of proteins and genetic material simultaneously within the lumen and on the surface of individual EVs with single-molecule sensitivity.

In this application note we discuss how characterization of sub-populations of EVs possessing one or more biomarkers enables: 

• Distinction of molecules within the lumen or on the surface of EVs

• Association of unique molecular signatures to EVs of a specific size

• Investigation of the function of DNA on the EV surface

• Understanding the unique role of EV subtypes in cancer and other diseases

To discover more about how super-resolution microscopy can be used in EV research, visit our EV imaging series articles and EV hub.