Quantitative super-resolution reveals nanoscale
recruitment of GABA_A receptors following
Bicuculline treatment

The Nanoimager is capable of performing multicolor super-resolution imaging in neuronal cultures. Among these techniques, dSTORM is commonly used to determine the molecular organization of protein complexes in synapses. With the Nanoimager it is possible to:

• Visualize synaptic protein organization with 20 nm resolution.
• Perform multicolor imaging of synaptic protein complexes, providing co-localization information of different targets at the nanometer scale.
• Determine quantitative subsynaptic parameters, such as the area, density and number of protein clusters per synapse or relative protein number per cluster

To discover more about how super-resolution microscopy can be used in Neuroscience, visit our Neuroscience hub.