Quantitative super-resolution reveals nanoscale
recruitment of GABAA receptors following
Bicuculline treatment

In this app note, we discuss how super-resolution microscopy can be used to reveal changes to nanoscale receptor recruitment in neural synapses.

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The Nanoimager is capable of performing multicolor super-resolution imaging in neuronal cultures. Among these techniques, dSTORM is commonly used to determine the molecular organization of protein complexes in synapses. With the Nanoimager it is possible to:

  • Visualize synaptic protein organization with 20 nm resolution.
  • Perform multicolor imaging of synaptic protein complexes, providing co-localization information of different targets at the nanometer scale.
  • Determine quantitative subsynaptic parameters, such as the area, density and number of protein clusters per synapse or relative protein number per cluster

To discover more about how super-resolution microscopy can be used in Neuroscience, visit our Neuroscience hub.

Download our 'Quantitative super-resolution reveals nanoscale recruitment of GABA receptors following Bicuculline treatment' app note here