Super-resolution characterization of oligomeric tau species in aggregates associated with neurodegeneration

The Nanoimager allows for super-resolution imaging of protein aggregates and toxic oligomeric species in neurodegenerative disorders.

In this application note we discuss how single-molecule localization techniques enable researchers to:

• Detect and characterize protein aggregates based on parameters such as size and shape

• Distinguish monomeric vs oligomeric protein species

• Investigate abnormalities in cellular organelles

• Accurately assess protein co-localization

To discover more about how super-resolution microscopy can be used in neuroscience research, visit our neuroscience hub.